Original articles

Original articles | Review articles | Book chapters | Doctoral theses

71. Anaya, K., Sus, N., Gadelha, C. & Frank, J. (2018) Development and validation of a rapid reversed-phase liquid chromatography method for CnAMP1 peptide quantification in human intestinal cell lines. Amino Acids (accepted for publication), IF 2.906. 

70. Venturelli, S., Niessner, H., Sinnberg, T., Berger, A., Burkard, M., Urmann, C., Donaubauer, K., Böcker, A., Leischner, C., Riepl, H., Frank, J., Lauer, U.M., Garbe, C. & Busch, C. (2018) 6- and 8-Prenylnaringenin, novel natural histone deacetylase inhibitors found in hops, exert antitumor activity on melanoma cells. Cell Physiol Biochem (accepted for publication), IF 5.5.

69. Irías-Mata, A., Sus, N., Flory, S., Stock, D., Woerner, D., Podszun, M. & Frank, J. (2018) α-Tocopherol transfer protein does not regulate the cellular uptake and intracellular distribution of α- and γ-tocopherols and -tocotrienols in cultured liver cells. Redox Biology 19: 28-36, IF 7.126.

68. Calvo-Castro, L. A., Sus, N., Schiborr, C., Bosy-Westphal, A., Duran, M. L., Fesenmeyer, D., Fesenmeyer, G. & Frank, J. (2018) Pharmacokinetics of vitamin E, γ-oryzanol and ferulic acid in healthy humans after the ingestion of a rice bran-enriched porridge prepared with water or with milk. Eur J Nutr (published online), IF 4.423.

67. Giller, K., Drews, B., Berard, J., Kienberger, H., Schmicke, M., Frank, J., Spanier, B., Daniel, H., Geisslinger, G. & Ulbrich, S. E. (2018) Bovine embryo elongation is altered due to maternal fatty acid supplementation. Biology of Reproduction (published online), IF 3.432.

66. Khayyal, M. T., El-Hazek, R. M., El-Sabbagh, W. A., Frank, J., Behnam, D. & Abdel-Tawab, M. (2018) Micellar solubilisation enhances the anti-inflammatory activities of curcumin and boswellic acids in rats with adjuvant-induced arthritis. Nutrition 54: 189-196; IF 3.420.

65. Calvo-Castro, L. A., Schiborr, C., David, F., Ehrt, H., Voggel, J., Sus, N., Behnam, D., Bosy-Westphal, A., & Frank, J. (2018) The oral bioavailability of trans-resveratrol from a grapevine-shoot extract in healthy humans is significantly increased by micellar solubilization. Mol Nutr Food Res 62: 1701057, IF 4.323.

64. Calvo-Castro, L. A., Burkard, M., Sus, N., Scheubeck, G., Leischner, C., Lauer, U. M., Bosy-Westphal, A., Hund, V., Busch, C., Venturelli, S. & Frank, J. (2018) The oral bioavailability of 8-prenylnaringenin from hops (Humulus lupulus L.) in healthy women and men is significantly higher than that of its positional isomer 6-prenylnaringenin in a randomized crossover trial. Mol Nutr Food Res 62: 1700838, IF 4.323.

63. Sus, N., Schlenz, J., Calvo-Castro, L. A., Burkard, M., Venturelli, S., Busch, C. & Frank, J. (2018) Validation of a rapid and sensitive reversed- phase liquid chromatographic method for the quantification of prenylated chalcones and flavanones in plasma and urine. NFS Journal 10: 1-9, SciteScore 2.83.

62. Irías-Mata, A., Stuetz, W., Sus, N., Hamman, S., Gralla, K., Cordero-Solano, A., Vetter, W. & Frank, J. (2017) Tocopherols, tocomonoenols and tocotrienols in oils of Costa Rican palm fruits: a comparison between six varieties and chemical vs. mechanical extraction. J Agric Food Chem 65: 7476–7482, IF 3.154.

61. Podszun, M. C., Jakobi, M., Birringer, M., Weiss, J. & Frank, J. (2017) The long chain α–tocopherol metabolite α-13’-COOH and γ-tocotrienol induce P-glycoprotein expression and activity by activation of the pregnane X receptor in the intestinal cell line LS 180. Mol Nutr Food Res 61: 1600605, IF 4.551. 

60. Frank, J., Schiborr, C., Kocher, A., Meins, J., Behnam, D., Schubert-Zsilavecz, M. & Abdel-Tawab, M. (2017) Transepithelial transport of curcumin in Caco-2 cells is significantly enhanced by micellar solubilisation. Plant Foods for Human Nutrition 72: 48-53, IF 2.276.

59. Hanschke, N., Kankofer, M., Locher, L., Höltershinken, M., Meyer, U., Frank, J., Dänicke, S. & Rehage, J. (2016) The effect of conjugated linoleic acid (CLA) supplements on oxidative and antioxidative status of dairy cows. Journal of Dairy Science 99: 8090-8102IF 2.573.

58. Hagl, S., Asseburg, H., Heinrich, M., Sus, N., Blumrich, E.-M., Dringen, R., Frank, J. & Eckert, G. P. (2016) Effects of long-term Rice Bran Extract supplementation on survival, cognition and brain mitochondrial function in aged NMRI mice. NeuroMolecular Medicine 18: 347-363, IF 3.678.

57. Dützmann, S., Schiborr, C., Kocher, A., Pilatus, U., Hattingen, E., Weissenberger, J., Gessler, F., Quick-Weller, J., Franz, K., Seifert, V., Frank, J. & Senft, C. (2016) Intratumoral concentrations and effects of orally administered micellar curcuminoids in glioblastoma patients. Nutr Cancer 68: 943-948, IF 2.322.

56. Kocher, A., Bohnert, L., Schiborr, C. & Frank, J. (2016) Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidaemic individuals. Mol Nutr Food Res 60: 1555-1563, IF 4.551.

55. Bortel, N., Armeanu-Ebinger, S., Schmid, E., Kirchner, B., Frank, J., Kocher, A., Schiborr, C., Warmann, S.W., Fuchs, J. & Ellerkamp, V.  (2015) Effects of curcumin in pediatric epithelial liver tumors: inhibition of tumor growth and alpha-fetoprotein in vitro and in vivo involving the NFkappaB and the beta-catenin pathways. Oncotarget 6: 40680–40691, IF 6.359.

54. Hagl, S., Berressem, D., Bruns, B., Sus, N., Frank, J., & Eckert, G. P. (2015) Beneficial effects of ethanolic and hexanic rice bran extract on mitochondrial function in PC12 cells and the search for bioactive components. Molecules 20: 16524-16539, IF 2.416.

53. Hagl, S., Kocher, A., Schiborr, C., Kolesova, N., Frank, J., & Eckert, G. P. (2015) Curcumin micelles improve mitochondrial function in neuronal PC12 cells and brains of NMRI mice - Impact on bioavailability. Neurochemistry International 89: 234-242, IF 3.092.

52. Hagl, S., Berressem, D., Grewal, R., Sus, N., Frank, J., & Eckert, G. P. (2016) Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice. Nutritional Neuroscience 19: 1-10, IF 2.274.

51. Sadri, H., Dänicke, S., Rehage, J., Frank, J., & Sauerwein, H. (2015) Tocopherols and tocotrienols in serum and liver of dairy cows receiving conjugated linoleic acids or a control fat supplement during early lactation. Journal of Dairy Science 98: 7034-7043, IF 2.573.

50. Kocher, A., Hagl, S., Schiborr, C., Eckert, G. P., & Frank, J. (2015) Concentrations of total curcuminoids in plasma, but not liver and kidney, are higher in 18- than in 3-months old mice. NFS Journal 1: 3-8.

49. Kocher, A., Schiborr, C., Behnam, D., & Frank, J. (2015) The oral bioavailability of curcuminoids in healthy humans is markedly enhanced by micellar solubilisation but not further improved by simultaneous ingestion of sesamin, ferulic acid, naringenin and xanthohumol. J Funct Foods 14: 183-191, IF 3.574.

48. Moazzami, A. A., Frank, S., Gombert, A., Sus, N., Bayram, B., Rimbach, G., & Frank, J. (2015) Non-targeted 1H-NMR-metabolomics suggest the induction of master regulators of energy metabolism in the liver of vitamin E-deficient rats. Food & Function 6: 1090-1097, IF 2.907.

47. Hongsibsong, S., Stuetz, W., Sus, N., Prapamontol, T., Grune, T., & Frank, J. (2014) Dietary exposure to continuous small doses of alpha-cypermethrin in the presence or absence of dietary curcumin does not induce oxidative stress in male Wistar rats. Toxicology Reports 1: 1106-1114.

46. Hagl, S., Heinrich, M., Kocher, A., Schiborr, C., Frank, J., & Eckert, G. P. (2014) Curcumin micelles improve mitochondrial function in a mouse model of Alzheimer's disease. The Journal of Prevention of Alzheimer’s Disease 1: 80-83.

45. Chin, D., Hagl, S., Höhn, A., Huebbe, P., Pallauf, K., Grune, T., Frank, J., Eckert, G. P. & Rimbach, G. (2014) Adenosine triphosphate concentrations are higher in the brain of APOE3 compared to APOE4 targeted-replacement mice and can be modulated by curcumin. Genes & Nutrition 9: 397, IF 3.329.

44. Chin, D., Huebbe, P., Frank, J., Rimbach, G., & Pallauf, K. (2014) Curcumin may impair iron status when fed to mice for six months. Redox Biology 2: 563-569, IF 6.337.

43. Podszun, M. C., Grebenstein, N., Spruss, A., Schlueter, T., Kremoser, C., Bergheim, I., & Frank, J. (2014) Dietary α-tocopherol and atorvastatin reduce high-fat-induced lipid-accumulation and down-regulate CD36 protein in the liver of guinea pigs. J Nutr Biochem 25: 573-579, IF 4.592.

42. Grebenstein, N., Schumacher, M., Graeve, L., & Frank, J. (2014) α-Tocopherol transfer protein is not required for the discrimination against γ-tocopherol in vivo but protects it from side-chain degradation in vitro. Mol Nutr Food Res 58: 1052-1060, IF 4.909.

41. Schiborr, C., Kocher, A., Behnam, D., Jandasek, J., Toelstede, S., & Frank, J. (2014) The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes. Mol Nutr Food Res 58: 516-527, IF 4.909.

40. Bayram, B., Rimbach, G., Frank, J., & Esatbeyoglu, T. (2014) A rapid method for glutathione quantification with potential application to glutathione disulfide, uric acid and ascorbic acid using high-performance liquid chromatography with coulometric electrochemical detection. J Agric Food Chem 62: 402-408, IF 2.906.

39. Mohrenz, I. V., Antonietti, P., Pusch, S., Capper, D., Balss, J., Voigt, S., Weissert, S., Mukrowsky, A., Frank, J., Senft, C., Seifert, V., vom Deimling, A., & Koegel, D. (2013) Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU- induced oxidative stress and cell death. Apoptosis 18: 1416-1425, IF 3.949.

38. Hagl, S., Kocher, A., Schiborr, C., Eckert, S., Ciobanu, I., Birringer, M., El-Askary, H., Helal, A., Khayyal, M. T., Frank, J., Müller, W. E., & Eckert, G. P. (2013) Rice bran extract protects from mitochondrial dysfunction in guinea pig brains. Pharmacol Res 76: 17-27, IF 4.436 

37. Schiborr, C., Schwamm, D., Kocher, A., Rimbach, G., Eckert, G. P., & Frank J. (2013) The senescence-accelerated mouse - prone 8 is not a suitable model for the investigation of cardiac inflammation and oxidative stress and their modulation by dietary phytochemicals. Pharmacol Res 74: 113-120, IF 4.436

36. Eckert, G. P., Schiborr, C., Hagl, S., Abdel-Kader, R., Müller, W. E., Rimbach, G., & Frank, J. (2013) Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse - prone 8. Neurochemistry International 65: 595-602, IF 2.857.

35. Podszun, M. C., Grebenstein, N., Hofmann, U., & Frank, J. (2013) High-dose supplementation with natural α-tocopherol does neither alter the pharmacodynamics of atorvastatin nor its phase I metabolism in guinea pigs. Toxicology and Applied Pharmacology 266: 452-458, IF 4.447.

34. Bayram, B., Ozcelik, B., Frank, J., & Rimbach, G. (2013) A Validated Method for the Determination of Selected Phenolics in Olive Oil Using High-Performance Liquid Chromatography with Coulometric Electrochemical Detection and a Fused-Core Colum. Food Chemistry 138: 1663-1669, IF 3.655.

33. Bayram, B., Esatbeyoglu, T., Schulze, N., Ozcelik, B., Frank, J., & Rimbach, G. (2012) Comprehensive Analysis of Polyphenols in 55 Extra Virgin Olive Oils by HPLC-ECD and Their Correlation with Antioxidant Activities. Plant Foods for Human Nutrition 67: 326-336, IF 2.505.  

32. Bayram, B., Nikolai, S., Huebbe, P., Ozcelik, B., Grimm, S., Grune, T., Frank, J., & Rimbach, G. (2012) Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence accelerated mouse prone 8. Age 35: 1205-1217, IF 3.948.

31. Grebenstein, N. & Frank, J. (2012) Rapid baseline-separation of all eight tocopherols and tocotrienols by reversed-phase liquid-chromatography with a solid-core pentafluorophenyl column and their sensitive quantification in plasma and liver. J Chromatogr A 1243: 39-46, IF 4.531. 

30. Egert, S., Tereszczuk, J., Wein, S., Müller, M.J., Frank, J., Rimbach, G. & Wolffram, S. (2013) Simultaneous ingestion of dietary proteins reduces the bioavailability of galloylated catechins from green tea in humans. Eur J Nutr 52: 281-288, IF 2.750. 

29. Bayram, B., Ozcelik, B., Grimm, S., Roeder, T., Schrader, C., Ernst, I., Wagner, A., Grune, T., Frank, J. & Rimbach, G.  (2012) A diet rich in olive oil phenolics reduces oxidative stress in the heart of SAMP8 mice by induction of Nrf2-dependent gene expression. Rejuvenation Research 15: 71-81, IF 3.826.

28. Pfeuffer, M., Auinger, A., Bley, U., Kraus-Stojanovic, I., Laue, C., Winkler, P., Rüfer, C., Frank, J., Boesch-Saadatmandi, C., Rimbach, G. & Schrezenmeir, J. (2013) Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammatory parameters in men with different APOE isoforms. Nutrition, Metabolism and Cardiovascular Disease 23: 403-409 , IF 3.731.

27. Boesch-Saadatmandi, C., Rimbach, G., Jungblut, A. & Frank, J. (2011) Comparison of tetrahydrofuran, fetal calf serum, and Tween 40 for the delivery of astaxanthin and canthaxanthin to HepG2 cells. Cytotechnology 63: 89-98, IF 1.207.

26. Schrader, C., Schiborr, C., Frank, J. & Rimbach, G. (2011) Curcumin induces paraoxonase-1 in cultured hepatocytes in vitro but not in mouse liver in vivo. Brit J Nutr 105: 167-170, IF 3.072.

25. Schiborr, C., Eckert, G. P., Weissenberger, J., Müller, W. E., Schwamm, D., Grune, T., Rimbach, G. & Frank, J. (2010) Cardiac oxidative stress and inflammation are similar in SAMP8 and SAMR1 mice and unaltered by curcumin and Ginkgo biloba extract intake. Curr Pharmaceut Biotechnol 11: 861-867, IF 3.455.

24. Schiborr, C., Eckert, G. P., Rimbach, G. & Frank, J. (2010) A validated method for the quantification of curcumin in plasma and brain tissue by fast narrow-bore high-performance liquid chromatography with fluorescence detection. Anal Bioanal Chem 397: 1917-25, IF 3.841. 

23. Fischer, A., Gaedicke, S., Frank, J., Döring, F. & Rimbach, G. (2010) Dietary vitamin E deficiency does not affect global and specific DNA methylation pattern in rat liver. Brit J Nutr 104: 935-940, IF 3.072.

22. Egert, S., Bosy-Westphal, A., Seiberl, J., Kürbitz, C., Settler, U., Plachta-Danielzik, S., Wagner, A. E., Frank, J., Schrezenmeir, J., Rimbach, G., Wolffram, S. & Müller, M. J. (2009) Quercetin reduces systolic blood pressure and plasma oxidized LDL concentrations in overweight subjects with a high-CVD-risk phenotype: a double-blinded, placebo-controlled crossover study. Brit J Nutr 102: 1065-1074, IF 3.446.

21. Augustin, K., Frank, J., Augustin, S., Langguth, P., Öhrvik, V., Witthöft, C., Rimbach, G. & Wolffram, S. (2009) Green tea extracts lower 5-methyltetrahydrofolate in rats only at very high dietary concentrations and do not affect folate concentrations in a human pilot study. J Physiol Pharmacol 60: 103-108, IF 2.631.

20. Wiegand, H., Bösch-Saadatmandi, C., Wein, S., Wolffram, S., Frank, J. & Rimbach, G. (2010) Dietary flavonoids do not affect vitamin E status in growing rats. J Anim Phsyiol Anim Nutr 94: 307-318 (published online in 2009), IF 1.106.

19. Gaedicke, S., Zhang, X., Huebbe, P., Boesch-Saadatmandi, C., Lou, Y., Wiswedel, I., Gardemann, A., Frank, J. & Rimbach, G. (2009) Dietary vitamin E, brain redox status and expression of Alzheimer’s disease relevant genes in rats. Brit J Nutr 102: 398-406, IF 3.446.

18. Frank, J., George, T. W., Lodge, J. K., Rodriguez-Mateos, A., Spencer, J. P. E., Minihane, A. M., & Rimbach, G. (2009) Daily consumption of an aqueous green tea extract supplement does not impair liver function or alter cardiovascular disease-risk biomarkers in healthy men. J Nutr 139: 58-62, IF 3.647.

17. Gaedicke, S., Zhang, X., Schmelzer, C., Lou, Y., Doering, F., Frank, J. & Rimbach, G. (2008) Vitamin E dependent microRNA regulation in rat liver. FEBS Lett 582: 3542-3546, IF 3.264. 

16. Egert, S., Wolffram, S., Bosy-Westphal, A., Bösch-Saadatmandi, C., Wagner, A., Frank, J., Rimbach, G. & Müller, M. J. (2008) Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr 138: 1615-1621, IF 3.647.

15. Frank, J., Lee, S., Leonard, S. W., Atkinson, J. K., Kamal-Eldin, A. & Traber, M. G. (2008) Sex differences in the inhibition of γ-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects. Am J Clin Nutr 87: 1723-1729, IF 6.740.

14. Augustin, K., Blank, R., Boesch-Saadatmandi, C., Frank, J., Wolffram, S. & Rimbach, G. (2008) Dietary green tea polyphenols do not affect vitamin E-status, antioxidant capacity and meat quality of growing pigs. J Anim Physiol Anim Nutr 92: 705-711, IF 0.911.

13. Jofre-Monseny, L., Huebbe, P., Stange, I., Boesch-Saadatmandi, C., Frank, J., Jackson, K., Minihane, A. M. & Rimbach, G. (2007) Influence of apolipoprotein E genotype and dietary alpha-tocopherol on redox status and C-reactive protein in apoE3 and apoE4 targeted replacement mice. Brit J Nutr 100: 44-53, IF 2.339. 

12. Moazzami, A. A., Frank, J., Lundh, T., Vessby, B. & Kamal-Eldin, A. (2007) Dietary Phytosterols Inhibit the Lipid Modulating Effects of Sesamin in Rats. Curr Topics Nutraceut Res 5: 93-98, IF 0.529.

11. Frank, J., Budek, A., Lundh, T., Parker, R. S., Swanson, J. E., Lourenco, B., Gago, J., Laranjinha, J., Vessby, B. & Kamal-Eldin, A. (2006) Dietary flavonoids with a catechol structure increase α-tocopherol in rats and protect the vitamin from oxidation in vitro. J Lipid Res 47: 2718-2725, IF 4.357. 

10. Hundhausen, C., Frank, J., Rimbach, G., Stoecklin, E., Muller, P. Y. & Barella, L. (2006) Effect of Vitamin E on Cytochrome P450 mRNA Levels in Cultured Hepatocytes (HepG2) and in Rat Liver. Cancer Genomics & Proteomics 3: 183-190.

9. Müller, P.Y., Netscher, T., Frank, J., Stöcklin, E., Rimbach, G., & Barella, L. (2005) Comparative Quantification of Pharmacodynamic Parameters of Chiral Compounds by Global Gene Expression Profiling. J Plant Physiol 162: 811-817, IF 1.403.

8. Frank, J., Kamal-Eldin, A. & Traber, M. G. (2004) Consumption of Sesame Oil Muffins Decreases the Urinary Excretion of γ-Tocopherol Metabolites in Humans. Ann N Y Acad Sci 1031: 365-367, IF 1.789.

7. Frank, J., Eliasson, C., Leroy-Nivard, D., Budek, A., Lundh, T., Vessby, B., Åman, P. & Kamal-Eldin, A. (2004) Dietary secoisolariciresinol diglucoside and its oligomers with 3-hydroxy-3-methyl glutaric acid decrease vitamin E levels in rats. Brit J Nutr 92: 169-176, IF 2.710.

6. Frank, J., Sundberg, B., Kamal-Eldin, A., Vessby, B. & Åman, P. (2004) Yeast-Leavened Oat Breads with High or Low Molecular Weight β-Glucan Do Not Differ in Their Effects on Blood Concentrations of Lipids, Insulin, or Glucose in Humans. J Nutr 134: 1384-1388, IF 3.245.

5. Ross, A. B., Chen, Y., Frank, J., Swanson, J. E., Parker, R. S., Kozubek, A., Lundh, T., Vessby, B., Åman, P. & Kamal-Eldin, A. (2004) Cereal Alkylresorcinols Elevate γ-Tocopherol Levels in Rats and Inhibit γ-Tocopherol Metabolism In Vitro. J Nutr 134: 506-510, IF 3.245.

4. Frank, J., Lundh, T., Parker, R. S., Swanson, J. E., Vessby, B. & Kamal-Eldin, A. (2003) Dietary (+)-Catechin and BHT Markedly Increase α-Tocopherol Concentrations in Rats by a Tocopherol-ω-Hydroxylase-Independent Mechanism. J Nutr 133: 3195-3199, IF 3.321.

3. Frank, J., Kamal-Eldin, A., Razdan, A., Lundh, T. & Vessby, B. (2003) The dietary hydroxycinnamate caffeic acid and its conjugate chlorogenic acid increase vitamin E and cholesterol concentrations in Sprague-Dawley rats. J Agric Food Chem 51: 2526-2531, IF 2.102. 

2. Frank, J., Kamal-Eldin, A., Lundh, T., Määttä, K., Törrönen, R. & Vessby, B. (2002) Effects of Dietary Anthocyanins on Tocopherols and Lipids in Rats. J Agric Food Chem 50: 7226-7230, IF 1.915.

1. Kamal-Eldin, A., Frank, J., Razdan, A., Tengblad, S., Basu, S. & Vessby, B. (2000) Effects of dietary phenolic compounds on tocopherol, cholesterol, and fatty acids in rats. Lipids 35: 427-435, IF 1.769. 

Original articles | Review articles | Book chapters | Doctoral theses